Nature：蛋白質(zhì)B-crystallin在多發(fā)性硬化中的作用

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生物谷報(bào)道：蛋白質(zhì)B-crystallin主要存在于眼睛的晶狀體中，它在多發(fā)性硬化中所發(fā)生的炎癥和損傷的發(fā)展過程中可能是關(guān)鍵的“引爆點(diǎn)”。過去，人們知道它是多發(fā)性硬化患者體內(nèi)1個(gè)主要免疫目標(biāo)。現(xiàn)在，用小鼠所做的研究工作表明，該蛋白在1個(gè)多發(fā)性硬化模型中還扮演1個(gè)保護(hù)角色。當(dāng)將其注射進(jìn)實(shí)驗(yàn)鼠體內(nèi)時(shí)，它起1種消炎和神經(jīng)保護(hù)因子的作用，并且還能使癱瘓發(fā)生逆轉(zhuǎn)。

原始出處:

Nature 448, 474-479 (26 July 2007) | doi:10.1038/nature05935; Received 6 March 2007; Accepted 17 May 2007; Published online 13 June 2007

Protective and therapeutic role for B-crystallin in autoimmune demyelination

Shalina S. Ousman1, Beren H. Tomooka2,3, Johannes M. van Noort4, Eric F. Wawrousek5, Kevin O'Conner6, David A. Hafler6, Raymond A. Sobel7, William H. Robinson2,3 & Lawrence Steinman1

Department of Neurology and Neurological Sciences, Stanford University
Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California 94305, USA
GRECC and,
Laboratory Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
Department of Biosciences, TNO Quality of Life, 2301 CE Leiden, The Netherlands
National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Center for Neurologic Disease, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA

Correspondence to: Lawrence Steinman1 Correspondence and requests for materials should be addressed to L.S. (Email: steinman@stanford.edu).

圖：Myelin antigen array analysis demonstrates antibody targeting of CRYAB in RRMS patients.

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